The UNAIDS Reference Group on Estimates, Modelling, and Projection worked with Avenir Health to use the Decision Makers Program Planning Toolkit (DMPPT) 2 Online to provide estimates of voluntary medical male circumcision (VMMC) coverage and to support countries in setting age- and geographic-specific targets. This article, published in a supplement to the Journal of the International AIDS Society, describes the methods and tools used for assembling, reviewing, and validating VMMC programme data as part of the 2021 UNAIDS Estimates process.