In a “stark wakeup call,” UNAIDS warns that the global response to HIV is not on track to meet it ambitious goals for epidemic control. This UNAIDS report, Miles to Go, calls for more investment in achieving the 90-90-90 goals for HIV testing, treatment, and viral suppression and for a greater emphasis on HIV prevention. Citing four studies of the impact of combination HIV prevention, the report emphasises that sufficient investment in proven approaches can produce results. The studies found that population-level declines in new HIV infections were achieved through expanded access to combination HIV prevention — including antiretroviral therapy and voluntary medical male circumcision (VMMC) — in regions in Uganda, Kenya, Eswatini, and South Africa. A section on VMMC describes innovative approaches that enabled programmes to reach an annual high of 4 million men and boys with VMMC in 14 priority countries in 2017 and the need to apply those approaches more widely to achieve the goal of 25 million VMMCs by 2020.